Antihistamines - Side effects 

Side effects of antihistamines 

Yellow Card Scheme 

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine that you're taking. It's run by a medicines safety watchdog called the Medicines and Healthcare Products Regulatory Agency (MHRA). See the Yellow Card Scheme website for more information.

First-generation antihistamines

Common side effects of first-generation antihistamines include:

  • drowsiness
  • impaired thinking
  • dry mouth
  • dizziness

It's important not to underestimate the effects of antihistamine-related drowsiness. Some first-generation antihistamines can impair abilities such as co-ordination, reaction times and judgment in the same way that alcohol consumption can.

Therefore it's very important that you do not drive or use power tools or heavy machinery after taking a first-generation antihistamine.

Less common side effects of first-generation antihistamines include:

  • insomnia – difficulty sleeping
  • nightmares
  • hallucinations – seeing or hearing things that aren't real
  • itchy skin

Rare side effects of first-generation antihistamines include:

  • rapid heartbeat
  • chest tightness

Contact your GP if you experience these rare side effects.

Second-generation antihistamines

A few people will experience drowsiness after taking second-generation antihistamines. If you find yourself feeling drowsy, do not drive, drink alcohol or use tools or machines.

As well as drowsiness, other side effects of second-generation antihistamines include:

These side effects are usually short-lasting and should pass quickly.

Rarer side effects include:

  • rapid heartbeat
  • chest tightness

Contact your GP if you have these rare side effects.

H2 receptor antagonists

Antihistamines that are used to treat stomach ulcers are known as H2 receptor antagonists. Side effects of this type of antihistamine are uncommon but may include:

  • show glossary terms
Antihistamines
Antihistamine medicine counteracts the action of histamine (a chemical released during an allergic reaction). For example, loratadine, hydroxyzine.
Drowsiness
Drowsiness is when someone feels extremely tired and uncontrollably near to sleep.
Fever
A high temperature, also known as a fever, is when someone's body temperature goes above the normal 37°C (98.6°F).
Heart
The heart is a muscular organ that pumps blood around the body.

Last reviewed: 11/05/2011

Next review due: 11/05/2013

Comments are personal views. Any information they give has not been checked and may not be accurate.

nb_pdr said on 28 July 2011

I have developed allergies and hayfever in recent years and have been almost forced to take these over the counter drugs. I am not sure what the active ingredient is for the batch i am using this summer however i have been experiencing almost complete loss of taste and smell. I can only think of these being the cause. Would be good to hear any comments on this.

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