When two or more medicines are taken at the same time, the effects of one of the medicines can be altered by the other. This is known as a drug-drug interaction. Aspirin can interact with other medicines.
Some of the more common interactions are listed below. However, this is not a complete list.
If you want to check that your medicines are safe to take with aspirin, ask your doctor or pharmacist, or read the patient information leaflet that comes with your medicine.
Anti-inflammatory painkillers
Aspirin should not be taken with anti-inflammatory painkillers such as diclofenac, ibuprofen, indometacin or naproxen, as this increases the risk of bleeding in the stomach.
Methotrexate
Aspirin can reduce the body's ability to remove methotrexate, and can therefore increase your risk of serious side effects from this drug.
SSRI antidepressants
Taking aspirin with SSRI antidepressants such as citalopram, fluoxetine, paroxetine, sertraline or venlafaxine may increase your risk of bleeding.
Warfarin
Warfarin is an anticoagulant that prevents your blood from clotting. Aspirin taken with warfarin can increase your risk of bleeding. However, there are some situations where you may be advised by your doctor to take aspirin and warfarin together.
