Brain aneurysm - Causes 

Causes of a brain aneurysm 

The brain requires a large supply of blood due to its size and complexity (the brain uses a quarter of all the blood in the human body).

The supply of blood is delivered to the brain by four main blood vessels, which run up the neck and into the brain. These blood vessels divide into smaller and smaller vessels in the same way that a trunk of a tree divides into branches and twigs.

Most aneurysms develop at the points where the blood vessels divide and branch off because these are the sections where the vessel walls are weakest.

Risk factors for a brain aneurysm

In some cases, brain aneurysms are caused by pre-existing (present from birth) weaknesses in the blood vessels.

There are also a number of risk factors that can cause you to develop a brain aneurysm. These are discussed below.

Smoking

Smoking cigarettes is a major risk factor for developing a brain aneurysm. A study published in 2010 found that 8 out of 10 people who were diagnosed with a brain aneurysm were smokers or had smoked in the past.

The risk is particualry high in people with a family history of brain aneurysm (see below).

Exactly why this is the case in unclear. There may be harmful substances in tobacco smoke that could damage the walls of blood vessels.

High blood pressure

High blood pressure can place increased pressure on the walls of the blood vessels inside the brain.

You are more likely to develop high blood pressure if you:

  • are overweight
  • have a relative with high blood pressure
  • are of African or Caribbean descent
  • eat a lot of salt
  • don't eat many fruit and vegetables
  • don't do enough exercise
  • drink a lot of coffee (or other caffeine-based drinks)
  • drink a lot of alcohol
  • are aged over 65

Read more about high blood pressure.

Family history

Family history can be a risk factor. Having a first-degree relative with a history of a brain aneurysm means that you're twice as likely to develop one than someone with no family history of the condition.

However, the increased risk is still small – only around 1 in 50 people with a family history of a ruptured brain aneurysm will go on to have a rupture themselves.

Cocaine

Cocaine abuse is another risk factor for brain aneurysms. Cocaine can inflame the walls of the blood vessels and raise your blood pressure. The combination of these two factors increases your risk of developing a brain aneurysm.

Autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic condition that causes multiple cysts to develop on the kidneys. Cysts are small sacs that are filled with fluid.

Around 1 in every 1,000 people is born with ADPKD. Of these people, around 1 in 20 will develop an aneurysm in the brain.

Read more about autosomal dominant polycystic kidney disease.

  • show glossary terms
Aneurysm
An aneurysm is a blood-filled sac that forms in a weakened part of a blood vessel.
Artery
Arteries are blood vessels that carry blood from the heart to the rest of the body.
Blood
Blood supplies oxygen to the body and removes carbon dioxide. It is pumped around the body by the heart.
Blood vessel
Blood vessels are the tubes in which blood travels to and from parts of the body. The three main types of blood vessels are veins, arteries and capillaries.
Brain
The brain controls thought, memory and emotion. It sends messages to the body controlling movement, speech and senses.
Cholesterol
Cholesterol is a fatty substance made by the body that is found in blood and tissue. It is used to make bile acid, hormones and vitamin D.
Genetic
Genetic is a term that refers to genes, the characteristics inherited from a family member.
High blood pressure
Hypertension is when the pressure of the blood in your bloodstream is regularly above 140/90 mmHG.
Obesity
Obesity is when a person has an abnormally high amount of body fat.
Platelets
Platelets are cells in the blood that control bleeding by plugging the broken blood vessel and helping the blood to clot.
Rupture
A rupture is a break or tear in an organ or tissue.

Last reviewed: 16/11/2011

Next review due: 16/11/2013

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