Anaphylaxis

Causes of anaphylaxis 

Anaphylactic shock occurs because your body's immune system overreacts in response to a particular substance (allergen) that you have been exposed to before (see the box, right).

When the allergen gets into your bloodstream, it causes the body to release massive amounts of the protein histamine and other chemicals.

Histamine causes:

  • blood vessels to widen, leading to a sudden severe lowering of blood pressure and narrowing of the airways in the lungs, and
  • blood vessels to leak, causing swelling (oedema) in the surrounding tissues and a further drop in blood pressure.

For detailed information on common food allergens, see External links.

  • show glossary terms

Glossary

Immune system
The immune system is the body's defence system, which helps protect it from disease, bacteria and viruses.
Blood vessels
Blood vessels are the tubes in which blood travels to and from parts of the body. The three main types of blood vessel are veins, arteries and capillaries.
Blood
Blood supplies oxygen to the body and removes carbon dioxide. It is pumped around the body by the heart.
Allergen
An allergen is a substance that reacts with the body's immune system and causes an allergic reaction.
Lungs
Lungs are a pair of organs in the chest that control breathing. They remove carbon dioxide from the blood and replace it with oxygen.

Last reviewed: 11/05/2009

Next review due: 11/05/2011

What are these?

Common triggers

Food:

  • nuts,
  • shellfish,
  • eggs,
  • milk,
  • wheat,
  • soy, and
  • sesame seeds.

Medicines:

  • penicillin and some other antibiotics,
  • non-steroidal anti-inflammatories (NSAIDs), such as aspirin and ibuprofen, and
  • anaesthetics and some painkillers.

Less common triggers:

  • bee or wasp stings,
  • latex (rubber),
  • exercise, and
  • exposure to cold air or water.